Dissertations Theses and Dissertations 2015 Regulation of.
A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs function via base-pairing with complementary sequences within mRNA molecules. As a result, these mRNA molecules are silenced, by one or more of the following.
In many conditions, including rheumatic diseases, microRNA expression has been found to be disturbed, with some microRNA upregulated and others downregulated. 115 In RA synovial fibroblasts, for instance, expression of microRNA 155, 146a, 203, 323, and 124 was found to be dysregulated. 116 MicroRNA is encoded in the genome in intergenic regions and overlapping introns or in the exons of other.
The third candidate microRNA targets a component of Polycomb Repressive Complex 1, a transcriptional repressor of HOX genes. Thus, the three candidate microRNAs may modulate posterior HOX gene expression associated with BE development. Barrett’s Esophagus (BE) is characterized by the appearance of an intestinal-like epithelium in the distal esophagus. The molecular mechanisms behind BE.
One such oncomir is microRNA-21 (miR-21) whose levels are often up-regulated in a number of cancers, including prostate cancer. MiR-21 increases the survival and invasiveness of cancer cells by suppressing its target tumor suppressor genes, namely programmed cell death 4 (PDCD4) and maspin. Thus, drugs which target miR-21 for inhibition could provide novel treatment options for metastatic.
MicroRNA (miRNA) are small nucleotide chains that have been the topic of research in recent years. These chains have been shown to be involved in affecting gene expression and silencing. This fact has led to further studies to try and identify miRNA’s relationship with stem cell’s potential for differentiation. The data for the following two studies provide evidence of the existence of.
Importantly, I discovered that a microRNA, called miR-29b, becomes induced with neuronal maturation and is able to inhibit apoptosis by regulating a key family of pro-apoptotic genes. This work provides the first example of a mammalian microRNA that can inhibit apoptosis in neurons. In contrast to the expression of miR-29b, which increases greatly during neuronal maturation, the vast majority.
MicroRNAs are a class of small RNAs of about 20 nucleotides long, which regulate cellular processes in animals and plants. Identifying microRNAs is one of the important tasks in microRNA and transcriptional studies. The main signal that is used for identifying these tiny molecules is the hairpin secondary structure of microRNA precursors. In this research, I propose to use a linear.
Exosomes are small, cargo-containing vesicles secreted by cells to facilitate intercellular communication. Of exosome cargos, microRNAs are especially interesting because of their involvement in gene regulation. Recently, our lab has shown that exosomes and their microRNA cargo are absorbed through the diet and elicit effects exogenously. Human and animal milk contain exosomes, which may have.
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Changes in gene expression and protein levels are an important aspect of cardioprotection in which short non-coding RNA known as miRNA may play a key regulatory role. We investigated the functions of several miRNAs in the context of two cardioprotective stimuli, ischemic preconditioning (IPC) and mesenchymal stem cell (MSC) paracrine effects.
Results: A total of 194 related literatures were retrieved in four databases. One hundred and thirty four differentially expressed miRNAs were found in the 12 microRNA expression profiling studies that compared endometriosis tissues with normal tissues, with 28 miRNAs reported in at least two studies, and 9882 candidate genes retrieved for 13 consistently expressed miRNAs.
Theses, Dissertations, and Projects. Title. MicroRNA regulated gene expression in Brugia malayi. Author. Tarja Yvanka De Soysa. Publication Date. 2011. Document Type. Honors Project. Department. Biological Sciences. Keywords. Filarial worms-Genetics, Nematodes-Genetics, Molecular parasitology, Small interfering RNA, Gene expression, Gene silencing, Filariasis-Prevention, Brugia malayi, Drug.
Theses and Dissertations. Title. Advancing Automated Methods for Microrna Profiling. Author. Kia N. Zellars, University of South Carolina. Date of Award. 2017. Document Type. Open Access Dissertation. Department. Biological Sciences. First Advisor. Francis Spinale. Abstract. The widespread influence of miRNAs in many biological processes and characteristic changes in expression profiles make.
Plants are constantly under attack from microbes and therefore employ complex and multilayered defense mechanisms to prevent infection. This work reports characterization of defense regulatory genes of Arabidopsis thaliana, including a microRNA, a family of histone demethylases, and a gene of unknown function. The microRNA miR167 was previously found to regulate flower development by.
Alterations in microRNA expression levels are time and location-dependent, differing at a key period of hypertension onset in NTS, but differing at the prehypertensive stage in RVLM. Using correlational relationships and network identification analysis, between microRNAs and mRNAs measured, we observed a double-negative regulatory motif consisting of a microRNA down-regulating a negative.
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Home University of Southern California Dissertations and Theses (16) Page 1 Reference URL Save to favorites. To link to the entire object, paste this link in email, IM or document To embed the entire object, paste this HTML in website To link to this page, paste this link in email, IM or document To embed this page, paste this HTML in website. Discovery of mature microRNA sequences within the.