Munich Graduate School for Evolution, Ecology and Systematics.

Chronic stress is associated with impairments in learning and memory, as well as changes in dendritic structure and synaptic connections of the hippocampus, a brain region key for spatial and episodic learning and memory. However, the cellular- and circuit- level mechanisms by which stress-induced structural synaptic changes impair learning and memory are not yet clear.

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The restoration of tissue homeostasis upon injury relies on the spatial and temporal coordination of multiple processes, including damage-induced apoptosis and compensatory proliferation of the surviving neighboring cells. In Drosophila, the JNK pathway plays a central role in tissue stress responses and promotes both apoptosis and proliferation.